Baree, Son of Kazan by James Oliver Curwood

According to Wikipedia: "Baree, Son of Kazan is the eponymous name of a 1917 novel about a wild wolfling pup named Baree. It was written by James Oliver Curwood as the sequel to Kazan. Baree, Son of Kazan is a story about a wild wolfdog pup sired by Kazan (1/4 wolf, 3/4 dog) and born of blind Greywolf (pure wolf). This story is about Baree's survival after being separated from his parents as a young pup. He eventually finds himself in the care of Nepeese and her father Pierrot, a trapper. He bonds with Nepeese, and the story goes from there. James Oliver Curwood took the well used "a boy and his dog" formula, and created a great adventure story about a girl and her dog. A successful formula featuring a strong heroine, rather than a male hero, that he used in many of his stories."