The significance of stem cells harvested from various sources came into limelight after reaping its beneficial effects in tissue engineering. However, there is a dearth of information specifically related to tissue engineering and regenerative dentistry. This book is an informative compendium which highlights on the basic principles of tissue engineering, the different approaches that can be adopted for the construction of oral mucosa model and three-dimensional cell culture, as well as its advantages and limitations directed towards the future directions; thus, triggering the interests of those who are keen to navigate further into this area of research