The monograph ‘Sustaining APEX: Universiti Sains Malaysia’s Mission to Transform Higher Education’ seeks to expand on and elaborate themes found in the previous two monographs in our Intellectual Discourse Series. In this monograph, we also take a deeper look at the problems of values and national development as well as issues of legitimacy and the efficacy of change and transformation in conditions of complex globalization. This monograph seeks to engage the difficult issues around science and technology and values, the social legitimacy of reform, and addresses the issues of newness, reputation, ranking and the problems of leadership. In doing this, we hope to tease out more of the implications of USM’s reform agenda and locate discussions of it within a broader discourse of globalization and its vicissitudes. The essential argument made in this monograph is that USM’s transformation agenda is a direct challenge to contemporary neo-liberal project for higher education. USM’s agenda entails a fuller idea and engagement with the educational and ethical mission of the university. Ecological sustainability, scientific and technological advancement as well as the sustainability of Malaysian culture, values, and sense of social justice is central to the mission of USM. Seeking to advance these in the current conditions of globalization and ensuring continued legitimacy for this project within such an environment is the challenge ahead.